Polymers in Medicine

Polim. Med.
Index Copernicus (ICV 2022) – 121.55
MEiN – 70
Average rejection rate – 39.13%
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2011, vol. 41, nr 4, October-December, p. 73–80

Publication type: review article

Language: English

Release Behavior of Drugs from Various Natural Gums and Polymers

Charakterystyka uwalniania leków z różnych naturalnych gum i polimerów

Anupama Singh1,, Pramod Kumar Sharma1,, Rishabha Malviya1,

1 Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology Bypass Road, Baghpat Crossing, NH-58, Meerut-250005, U.P., India

Abstract

Polymers are the high molecular weight compounds of natural or synthetic origin, widely used in drug delivery of formulations. These polymers are further classified as hydrophilic or hydrophobic in nature. Depending upon this characteristic, polymers exhibit different release behavior in different media. This property plays an important role in the selection of polymers for controlled, sustained or immediate release formulations. The review highlights the literatures related to the research made on several polymers regarding the release kinetics which made them a novel approach for modifying the action of the particular formulation.

Streszczenie

Praca jest przeglądem literatury, dotyczącej badań nad różnymi polimerami w odniesieniu do kinetyki uwalniania, które umożliwiają nowe podejście do modyfikowania działania określonych formuł farmakologicznych. Polimery są związkami pochodzenia naturalnego lub syntetycznego o dużej masie cząsteczkowej, szeroko używanymi w formułach dostarczających leki do organizmu. Polimery te są sklasyfikowane jako hydrofilowe lub hydrofobowe i wykazują różne stopnie rozpuszczalności w zależności od środowiska. Te własności odgrywają ważną rolę w wyborze polimerów do formuł z kontrolowanym, stałym lub natychmiastowym efektem uwalniania.

Key words

natural polymer, gum and mucilages, controlled drug delivery, biodegradable polymers

Słowa kluczowe

polimery, gumy, galaretki, kontrolowane uwalnianie leku, biowchłanialne polimery

References (55)

  1. Muhidinov Z., Bobokalonov J., Liu L. S., Fassihi R.: In: A Kinetic Study of Poorly Water Soluble Drug Released from Pectin Microcapsules Using Diffusion/Dissolution Model. New Delivery Systems for Controlled Drug Release from Naturally Occurring Materials, ACS Symposium Series (2008), 992, 193–208.
  2. Cicek H., Tuncel A., Tuncel, M., Piskin, E.: Degradation and drug release characteristics of monosize polyethylcyanoacrylate microspheres. J. Biomater. Sci. Polym. (1995), 6, 845–856.
  3. Mi F. L., Lin Y. M., Wu Y. B., Shyu S. S., Tsai Y. H.: Chitin/PLGA blend microspheres as a biodegradable drug-delivery system: phase-separation, degradation and release behavior. Biomater. (2002), 23, 3257–3267.
  4. Zhang Y., Chu C. C.: In vitro release behavior of insulin from biodegradable hybrid hydrogel networks of polysaccharide and synthetic biodegradable polyester. J. Biomater. Appl. (2002), 16, 305–325.
  5. Abraham G. A., Gallardo A., San Roman J., Fernandez-Mayoralas A., Zurita M., Vaquero J.: Polymeric matrices based on graft copolymers of PCL onto acrylic backbones for releasing antitumoral drugs. J. Biomed. Mater. Res. (2003), 6 (4A), 638–647.
  6. Calandrelli L., De Rosa G., Errico M. E., La Rotonda M. I., Laurienzo P., Malinconico M., Oliva A., Quaglia F.: Novel graft PLLAbased copolymers: potential of their application to particle technology. J. Biomed. Mater. Res. (2002), 62, 244–253.
  7. Liu J., Xiao Y., Allen C.: Polymer-drug compatibility: a guide to the development of delivery systems for the anticancer agent, ellipticine. J. Pharm. Sci. (2004), 93, 132–143.
  8. Chen B. H., Lee D. J.: Slow release of drug through deformed coating film: effects of morphology and drug diffusivity in the coating film. J. Pharm. Sci. (2001), 90, 1478–1496.
  9. Tunon A., Grasjo J., Alderborn G.: Effect of intragranular porosity on compression behaviour of and drug release from reservoir pellets. Eur. J. Pharm. Sci. (2003), 19, 333–344.
  10. Fulzele S. V., Satturwar P. M., Kasliwal R. H., Dorle A. K.: Preparation and evaluation of microcapsules using polymerized rosin as a novel wall forming material. J. Microencapsul. (2004), 21, 83–89.
  11. Bhise K. S., Dhumal R. S., Chauhan B., Paradkar A., Kadam S. S.: Effect of oppositely charged polymer and dissolution medium on swelling, erosion, and drug release from chitosan matrices. AAPS Pharm. Sci. Tech. (2007), 8 (2), E110–E118.
  12. Kumar S. V., Sasmal D., Pal S. C.: Rheological Characterization and Drug Release Studies of Gum Exudates of Terminalia catappa Linn. AAPS Pharm. Sci. Tech. (2008), 9 (3), 885–890.
  13. El-Gazayerly O. N.: Release of pentoxifylline from xanthan gum matrix tablets. Drug Dev. Ind. Pharm. (2003), 29 (2), 241–246.
  14. Gane san S.: Traditional oral care medicinal plants survey of Tamil Nadu. Natural Product Radiance. (2008), 7 (2), 166–172.
  15. Sachan N. K., Bhattacharya A.: Feasibility of Assam Bora rice based matrix microdevices for controlled release of water insoluble drug. Int. J. Pharm. Pharmaceut. Sci. (2009), 1 (1), 96–102.
  16. Mughal M. A., Iqbal Z., Neau S. H.: Guar gum, xanthan gum, and HPMC can define release mechanisms and sustain release of propranolol hydrochloride. AAPS Pharm. Sci. Tech. (2011), 12 (1), 77–87.
  17. Syeda I. A., Mangamoorib L. N., Rao Y. M.: Formulation and characterization of matrix and triple-layer matrix tablets for controlled delivery of Metoprolol tartrate. Int. J. Pharmaceut. Sci. Drug Res. (2011), 3 (1), 23–28.
  18. Coviello T., Matricardi P., Marianecci C., Alhaique F.: Polysaccharide hydrogels for modified release formulations. J. Control. Release. (2007), 119, 5–24.
  19. Sjoberg H., Persson S., Caram-Lelham N.: How interactions between drugs and agarose– carrageenan hydrogels influence the simultaneous transport of drugs. J. Control. Release. (1999), 59, 391–400.
  20. Liu J., Lin S., Li L., Liu E.: Release of theophylline from polymer blend hydrogels. Int. J. Pharm. (2005), 298, 117–125.
  21. Rosario N. L., Ghaly E. S.: Matrices of watersoluble drug using natural polymer and direct compression method. Drug Dev. Ind. Pharm. (2002), 28 (8), 975–988.
  22. Bhatia M. S., Deshmukh R., Choudhari P., Bhatia N. M.: Chemical modification of pectins, Characterization and Evaluation for Drug Delivery. Scientia Pharmaceutica (2008), 76, 775–784.
  23. Patel N. V., Patel J. K., Shah S. H., Patel J. J.: Design, development and in vitro evaluation of Mesalamine tablets containing Pectin and Chitosan for colon-specific drug delivery. Int. J. Res. Pharm. Sci. (2010), 1 (2), 94–102.
  24. Tonnesen H. H., Karlsen J.: Alginate in Drug Delivery Systems. Drug Dev Ind. Pharm. (2002), 28 (6), 621–630.
  25. Malviya R., Srivastava P., Bansal M., Sharma P. K.: Formulation and Optimization of sustained release matrix tablets of Diclofenac sodium using pectin as release modifier. Int. J. Drug Dev. Res. (2010), 2 (2), 330–335.
  26. Sahoo R., Sahoo S., Nayak P. L.: Release behavior of anticancer drug Paclitaxel from tamarind seed polysaccharide galactoxyloglucan. Eur. J. Sci. Res. (2010), 47 (2), 197–206.
  27. Rao P. S., Ghosh T. P., Krishna S.: Extraction and purification of tamarind seed polysaccharide. J. Sci. Ind. Research. (1946), 4, 705.
  28. Sumathi S., Ray A. R.: Release behavior of drugs from Tamarind Seed Polysaccharide tablets. J. Pharm. Pharmaceut. Sci. (2002), 5 (1), 12–18.
  29. Kumar P., Battu G. K., Lova Raju G., Kotha N. S.: Preparation and evaluation of sustained release matrix tablets of Lornoxicam using tamarind seed polysaccharide. Int. J. Pharma. Res. Dev. (2011), 2 (12), 89–98.
  30. Rajesh K. S., Venkataraju M. P., Gowda D. V.: Effect of hydrophilic natural gums in formulation of oral-controlled release matrix tablets of Propranolol hydrochloride. Pak. J. Pharm. Sci. (2009), 22 (2), 211–219.
  31. Malviya R., Srivastava P., Bansal M., Sharma P. K.: Formulation, evaluation and comparison of sustained release matrix tablets of Diclofenac sodium using tamarind gum as release modifier. Asian J Pharm. Clin. Res. (2010), 3 (3), 238–241.
  32. Tapia C., Costa E., Terraza C., Munita A. M., Yazdani-Pedram M.: Study of prolonged release of theophylline from polymeric matrices based on grafted chitosan with acrylamide. Pharmazie (2002), 57 (11), 744–749.
  33. Jeevanandham S., Sekar M., Dhachinamoorthi D., Muthukumaran M., Sriram N., Joysaruby J.: Sustain-release of various drugs from Leucaena leucocephala polysaccharide. J Young Pharm. (2010), 2 (1), 15–20.
  34. Deod har U. P., Paradkar A. R., Purohit A. P.: Preliminary evaluation of Leucaena leucocephala seed gum as a tablet binder. Drug Dev. Ind. Pharm. (1998), 24 (6), 577–582.
  35. Verma P. R. P., Razdan B.: Studies on disintegrant action of Leucaena leucocephala seed gum in Ibuprofen tablet and its mechanism. J. Sci. Ind. Research. (2007), 66, 550–557.
  36. Mazumder R., Nath L. K., Haque A., Maity T., Choudhury P. K., Shrestha B., Chakraborty M., Pal R. N.: Formulation and in vitro evaluation of natural polymers based microspheres for colonic drug delivery. Int. J. Pharm. Pharmaceut. Sci. (2010), 2 (1), 211–219.
  37. Varshosaz J., Tavakoli N., Kheirolahi F.: Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of Tramadol Hydrochloride. AAPS Pharm. Sci. Tech. (2006), 7 (1), E1–E7.
  38. Deshmukh V. N., Singh S. P., Sakarkar D. M.: Formulation and evaluation of sustained release Metoprolol Succinate tablet using hydrophilic gums as release modifiers. Int. J. Pharm. Tech. Res. (2009), 1 (2), 159–163.
  39. Yadav A. S., Kumar P. A., Vinod R., Rao B. S., Kulkarni S. V.: Design and evaluation of guar gum based controlled release matrix tablets of Zidovudine. J. Pharmaceut. Sci. Technol. (2010), 2 (3), 156–162.
  40. Soni M. L., Kumar M., Namdeo K. P.: Sodium alginate microspheres for extending drug release: formulation and in vitro evaluation. I nt . J. Drug De l . (2010), 2 (1), 64–68.
  41. Kesavan K., Nath G., Pandit J. K.: Sodium alginate based mucoadhesive system for Gatifloxacin and its in vitro antibacterial activity. Scientia Pharmaceutica (2010), 78, 941–957.
  42. Patel B., Patel P., Bhosale A., Hardikar S., Mutha S., Chaulang G.: Evaluation of Tamarind Seed Polysaccharide (TSP) as a mucoadhesive and sustained release component of Nifedipine buccoadhesive tablet & comparison with HPMC and Na CMC. Int. J. Pharm. Tech. Res. (2009), 1 (3), 404–410.
  43. Blessing O. G., Onwugbuta-Enyi J.: Phloem mechanism in Terminalia catappa and Cocos nucifera and their implications in the continuty of the rain forest. World J Agri. Sci. (2009), 5 (1), 132–134.
  44. Odeniy M. A., Jaiyeoba K. T.: Optimization of ascorbic acid tablet formulations containing hydrophilic polymers. Farmacia (2009), 57 (2), 157–166.
  45. Batham P., Pinsonneaul R. T., Procter B. G.: An in utero/chronic toxicity/carcinogenicity study of gellan gum administered in the diet to the rat (in utero phase). Bio-Research Laboratories Ltd., Montreal, Canada, (1985).
  46. Batham P., Kalichman S. G., Osborne B. E.: A 52-week oral toxicity study of gellan gum in the beagle dog. Bio – Research Laboratories Ltd., Montreal, Canada, (1986).
  47. Nep E. I., Conway B. R.: Polysaccharide gum matrix tablets for oral controlled delivery of Cimetidine. J. Pharm. Sci. Res. (2010), 2 (11), 708–716.
  48. Dabhi M. R., Nago ri S. A., Gohel M. C., Parikh R. K., Sheth N.R.: Formulation development of smart gel periodontal drug delivery system for local delivery of chemotherapeutic agents with application of experimental design. Drug Deliv. (2010), 17 (7), 520–531.
  49. Agnihotri S. A., Jawalkar S. S., Aminabhavi T. M.: Controlled release of cephalexin through gellan gum beads: Effect of formulation parameters on entrapment efficiency, size and drug release. Eur. J. Pharm. Biopharm. (2006), 63 (3), 249–261.
  50. Prasanthi N. L., Manikiran S. S., Rao R. R.: Effect of hydrophilic polymers on the formulation and evaluation of Propranolol hydrochloride matrix tablets. The Ind. Pharmacists (2010), 8 (12), 61–66.
  51. Attama A. A., Nwabunze O. J.: Mucuna gum microspheres for oral delivery of glibenclamide: In vitro evaluation. Acta Pharm. (2007), 57, 161– 171.
  52. Krishnaiah Y. S., Karthikeyan R. S., Satyanarayana V.: A three-layer guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate. Int. J. Pharm. (2002), 241, 353–366.
  53. Munday D. L., Cox P. J.: Compressed xanthan and karaya gum matrices: Hydration, erosion and drug release mechanisms. Int. J. Pharm. (2000), 203, 179–192.
  54. Gangadharappa H. V., Rahamath-Ulla M., Pramod-Kumar T. M., Shakeel F.: Floating drug delivery system of verapamil hydrochloride using karaya gum and HPMC. Clinical Research and Regulatory Affairs (2010), 2 (1), 13–20.
  55. Moin A., Shivakumar H. G.: Formulation and in vitro evaluation of sustained-release tablet of Diltiazem: Influence of hydrophilic gums blends. J. Pharm. Res. (2010), 3 (3), 600–604.
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