Polymers in Medicine

Polim. Med.
Index Copernicus (ICV 2022) – 121.55
MEiN – 70
Average rejection rate – 39.13%
ISSN 0370-0747 (print)
ISSN 2451-2699 (online) 
Periodicity – biannual

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Polymers in Medicine

2015, vol. 45, nr 2, July-December, p. 67–72

doi: 10.17219/pim/59137

Publication type: original article

Language: English

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Creative Commons BY-NC-ND 3.0 Open Access

Effect of Calcium Chloride on Release Behavior of Babul (Acacia nilotica) gum Microbeads

Pramod Kumar Sharma1,A,E, Rishabha Malviya1,A

1 Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, India

Abstract

Background. Oral delivery of drugs is the most common method, but due to the inability of drugs to restrain and localize in the gastro-intestinal tract, oral administration of drugs in conventional dosage forms have short-term limitations. Carrier technology may provide many approaches for the delivery of drugs by coupling the drug to a carrier particle, such as Microspheres, nanoparticles and liposomes, which modulate the release and absorption characteristics of the drug.
Objectives. The aim of this study was to prepare Diclofenac sodium microspheres using a natural polymer and show the effect of calcium chloride on the release behavior of microspheres. The microspheres of Diclofenac sodium were successfully developed by ionic gelation technique using natural polymer babul gum with sodium alginate.
Material and Methods. Diclofenac Sodium was received as a gift sample from Aegis Pharmaceuticals Pvt. Ltd., Roorkee. Acacia nilotica gum was purchased from Ghaziabad and purification was done in the laboratory. All other excipients used analytical grade method. The microspheres of diclofenac sodium were prepared by Ionic gelation method using a natural polimer, i.e. Acacia nilotica. Calcium chloride (5% solution) was used as a cross-linking agent. In this research article all the data was presented as averages and standard deviations.
Results. Five formulations were successfully prepared, i.e. F1, F2, F3, F4 and F5. All the formulations were evaluated for micromeritic properties, particle size analysis, percentage yield, drug content, drug entrapment efficacy, percent moisture loss, swelling index and in vitro dissolution studies. The size of the microspheres varied between 14.55 ± 0.29 to 20.18 ± 0.15 μm and as high as 81.51 ± 0.14% entrapment efficiency for babul gum was obtained.
Conclusion. Batch F1 and F5 was found to release the drug 91.35% and 75.48% respectively for 6 hrs. The formulations were found to be effective in providing controlled release of drug for a prolonged period of time.

Key words

microspheres, Acacia nilotica, Diclofenac sodium, Ionic gelation technique, in-vitro drug release

References (23)

  1. Kaurav H., Kumar S.L.H., Kaur A.: Mucoadhesive microspheres as carriers in drug delivery: a review. Int. J. Drug Dev. & Res. 2012, 4, 21–34.
  2. Prasanth V.V., Chakraborthy A., Mathew S.T., Mathapan R.: Microspheres: an overview. Int. J. Res. Pharm. Biomed. Sci. 2011, 2, 332–338.
  3. Prabu S., Shirwaikar S.S., Shirwaikar A., Kumar A.: Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac. ARS Pharm. 2009, 50, 51–62.
  4. Chowdary K.P.R., Narayana T.V., Rao Y.S.: Preparation and evaluation of mucoadhesive microspheres. The Indian pharmacist 2006, 5, 29–34.
  5. Thanoo B.C., Sunny M.C., Jayakrishnan A.: Cross-linked chitosan microspheres: preparation and evaluation as a matrix for the controlled release of pharmaceuticals. J. Pharm. Pharmacol. 1992, 44, 283–286.
  6. Arora V., Mishra P.B., Kumar S., Vashishta N.: Formulation and evaluation of egg albumin based delayed release microspheres of itraconazol. Am. J. Pharmtech. Res. 2013, 3, 490–500.
  7. Deshpande A.A., Rhodes C.T., Shah N.H., Malick A.W.: Controlled-release drug delivery systems for prolonged gastric residence: an overview. Drug Dev. Ind. Pharm. 1996, 22, 531–539.
  8. Chella N., Yada K.K., Vempati R.: Preparation and evaluation of ethylcellulose microspheres containing diclofenac sodium by novel w/o/o emulsion method. J. Pharm. Sci. & Res. 2010, 2, 884–888.
  9. Alagusundaram M., Chetty C.M.S., Umashankari K., Badarinath A.V., Lavanya C., Ramkanth S.: Microsphere as a novel drug delivery system – a review. Int. J. Chem. Tech. Res. 2009, 1, 526–534.
  10. Singh A., Sharma P.K., Malviya R.: Sustained drug delivery using mucoadhesive microspheres: the basic concept, preparation methods and recent patents. Recent Patents on Nanomedicine 2012, 2, 62–77.
  11. Mathew T.S., Gayathri D.S., Sandhya K.V.: Formulation and evaluation of ketorolac tromethamine-loadedalbumin microspheres for potential intramuscular administration. AAPS Pharm. Sci. Tech. 2007, 8, 1–9.
  12. Drug bank, Drug profile, Diclofenac Sodium http://www.drugbank.ca/drugs/DB00586.
  13. Ali A., Akhtar N., Khan B.A., Khan M.S. Rasul A., Zaman S.U., Khalid N., Waseem K., Mahmood T., Ali L.: Acacia nilotica: a plant of multipurpose medicinal uses. J. Med. Plants Res. 2012, 6, 1492–1496.
  14. Malviya R.: Extraction characterization and evaluation of selected mucilage as pharmaceutical excipient. Polim. Med. 2011, 41, 39–44.
  15. Sahoo S.K., Mohapatra S., Dhal S.K., Behera B.C., Barik B.B.: Formulation of floating microspheres of ciprofloxacin hydrochloride by crosslinking agent. Ind. Pharm. 2007, 6, 65–68.
  16. Lachman L., Liberman H.A., Kanig J.L.: The theory and practice of industrial pharmacy. Varghese Publishing House, Mumbai 1990, 3rd ed., 296–302.
  17. Mathew T.S., Gayathri D.S., Sandhya K.V.: Formulation and evaluation of ketorolac tromethamine-loaded albumin microspheres for potential intramuscular administration. AAPS Pharm. Sci. Tech. 2007, 8, 1–9.
  18. Chaturvedi S., Sharma P.K., Visht S., Tyagi S.: Comparison of emulsion and ionic gelation method of preparation of mucoadhesive microsphere. The Pharm. Innovation 2012, 1, 1–9.
  19. Kaurav H., Hari Kumar S.L., Kaur A.: Mucoadhesive microspheres as carriers in drug delivery: a review. Int. J. Drug Develop. & Res. 2012, 4, 21–34.
  20. Mladenovska K., Raicki R.S., Janevik E.I., Ristoski T., Pavlova M.J., Kavrakovski Z., Dodov M.G., Goracinova K.: Colonspecific delivery of 5-aminosalicylic acid from chitosan-Ca-alginate microparticles. Int. J. Pharm. 2007, 342, 124–136.
  21. Patel J.K., Patel R.P., Amin A.F., Patel M.M.: Formulation and evaluation of mucoadhesive glipizide microspheres. AAPS Pharm. Sci. Tech. 2005, 6, 49–55.
  22. Mankala et al.: Preparation and characterization of mucoadhesive microcapsules of gliclazide with natural gums. S. J. Pharm. Sci. 2011, 4, 38–48.
  23. Malviya R.: Extraction and characterization of selected mucilage as a pharmaceutical excipients. Polim. Med. 2011, 41, 3, 39–44.